Anti-centromere protein A antibodies are used for the immunodetection of the protein encoded by the CENPA gene. In humans, the canonical protein has a reported length of 140 amino acid residues and a mass of 16 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Histone H3 protein family, it is known to be involved with cell division. Post-translational modifications have been described, including methylation, ubiquitination, protein cleavage and phosphorylation. Other names for this target antigen include histone H3-like centromeric protein A, centromere autoantigen A, centromere protein A, 17kDa, centromere-specific histone, and CenH3. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species. Over 180 citations in the literature describe the use of centromere protein A antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.