Fig 2: (A) Positivity rate of nuclear CENP-A in epithelial cells according to the WHO histological subtype (Fischer’s exact test, p = 0.01). (B) Schematic representation of the associations between CENP-A H-score and WHO subtype (Mann–Whitney U test, p = 0.01 for cytoplasmic and p = 0.02, for nuclear). (C) CENP-A H-score expression according to Masaoka–Koga stage (Mann–Whitney U test, IV vs. I/II/III, p = 0.04 for nuclear, p > 0.10 for cytoplasmic). (D,E) Kaplan–Meier survival rates according to nuclear (D) and cytoplasmic (E) CENP-A positivity (log-rank test, p > 0.10 for nuclear and p = 0.03 for cytoplasmic). Small diamonds in (B,C) correspond to outliers.

Fig 3: (A–F) TCGA TETs cohort survival analysis for DAXX expression (A,B), CENP-A (C,D) and HJURP (E,F). Survival analysis was performed with GEPIA2, using median as a cutoff. (G) TiMER2.0 analysis of TCGA TETs expression profile revealing a strong correlation between the expression of CENP-A and HJURP.