Anti-castor zinc finger 1 antibodies are used for the immunodetection of the protein encoded by the CASZ1 gene. In humans, the canonical protein has a reported length of 1759 amino acid residues and a mass of 190.1 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is found to be expressed in the heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain. It is noted to be involved in the regulation of transcription and regulation of neuron differentiation.
The castor zinc finger 1 marker can be used to characterize Eccentric Medium Spiny Neurons and Medulla Oblongata Splatter Neurons.* Other names for this target antigen include CST, ZNF693, dJ734G22.1, zinc finger protein castor homolog 1, and CAS11. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of castor zinc finger 1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4