Anti-HRC antibodies are used in the immunodetection of the protein histidine rich calcium binding protein. In humans, the canonical protein has a reported length of 699 amino acid residues and a mass of 80.2 kDa. It is notably expressed in the testis, skeletal muscle, and heart muscle. A member of the HRC protein family, HRC is believed to play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. Synonyms for this target antigen include sarcoplasmic reticulum histidine-rich calcium-binding protein. HRC gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some HRC antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.