Anti-DIO1 antibodies are used in the immunodetection of the protein iodothyronine deiodinase 1. In humans, the canonical protein has a reported length of 249 amino acid residues and a mass of 28.9 kDa. Its subcellular localization is in the ER. Up to 9 different isoforms have been reported for this protein. A member of the Iodothyronine deiodinase protein family, DIO1 is known to be important for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). The DIO1 gene has been associated with the disease, Thyroid hormone metabolism. Synonyms for this target antigen include THMA2, TXDI1, type I iodothyronine deiodinase, DIOI, deiodinase, iodothyronine type I, and 5DI. DIO1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of DIO1 antibodies have been mentioned in research publications and have associated citations. ELISA and Western Blot are common applications for these antibodies.