Anti-LTBP1 antibodies are used in the immunodetection of the protein latent transforming growth factor beta binding protein 1. In humans, the canonical protein has a reported length of 1721 amino acid residues and a mass of 186.8 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 5 different isoforms have been reported for this protein. It is notably expressed in the aorta. A member of the LTBP protein family, LTBP1 is a reported key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Post-translational modifications have been described, including O-glycosylation.
The LTBP1 marker can be used to identify Hypothalamus Mammillary Body Neurons and Midbrain-Derived Inhibitory Neurons.* Synonyms for this target antigen include TGF-beta1-BP-1, transforming growth factor beta-1-binding protein 1, and ARCL2E. LTBP1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4