Anti-LAMA3 antibodies are used in the immunodetection of the protein laminin subunit alpha 3. In humans, the canonical protein has a reported length of 3333 amino acid residues and a mass of 366.6 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 4 different isoforms have been reported for this protein. LAMA3 is known to be involved with cell adhesion and endodermal cell differentiation. Post-translational modifications have been described, including glycosylation.
The LAMA3 marker can be used to identify Amygdala Excitatory Neurons, Eccentric Medium Spiny Neurons, and Gray Matter CGE Interneurons.* Synonyms for this target antigen include E170, JEB2A, JEB2B, JEB2C, LAMNA, LOCS, BM600 150kD subunit, and BM600. LAMA3 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of LAMA3 antibodies have been mentioned in research publications and have associated citations. ELISA, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4