Anti-EDEM2 antibodies are used in the immunodetection of the protein ER degradation enhancing alpha-mannosidase like protein 2. In humans, the canonical protein has a reported length of 578 amino acid residues and a mass of 64.8 kDa. Its subcellular localization is in the ER. Up to 2 different isoforms have been reported for this protein. It is found to be widely expressed in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in the brain and skeletal muscle. A member of the Glycosyl hydrolase 47 protein family, EDEM2 is reported to be involved in endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Synonyms for this target antigen include ER degradation-enhancing alpha-mannosidase-like 2, ER degradation-enhancing-mannosidase-like protein 2, and ER degradation enhancer, mannosidase alpha-like 2. Some EDEM2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.