Anti-AQP2 antibodies are used in the immunodetection of the protein aquaporin 2. In humans, the canonical protein has a reported length of 271 amino acid residues and a mass of 28.8 kDa. Its subcellular localization is in the cytoplasmic vesicles, Golgi, and cell membrane. It is reported to be expressed in collecting tubules in the kidney medulla. It is a member of the MIP/aquaporin (TC 1.A.8) protein family. Post-translational modifications have been described, including N-glycosylation and phosphorylation.
The AQP2 marker can be used to identify Cortical Collecting Duct Principal Cells, Inner Medullary Collecting Duct Cells, Connecting Tubule Principal Cells, Collecting Duct Principal Cells, and Outer Medullary Collecting Duct Principal Cells.* Synonyms for this target antigen include NDI2, WCH-CD, ADH water channel, aquaporin 2 (collecting duct), aquaporin-CD, and AQP-CD. AQP2 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4