Anti-APLN antibodies are used in the immunodetection of the protein apelin. In humans, the canonical protein has a reported length of 77 amino acid residues and a mass of 8.6 kDa. It has been described to be a secreted protein. It is reported to be expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. A member of the Apelin protein family, APLN is known to be involved with angiogenesis and immune response pathways. Post-translational modifications have been described, including protein cleavage.
The APLN marker can be used to identify Aerocyte Capillary (aCap) Cells.* Synonyms for this target antigen include XNPEP2, AGTRL1 ligand, APJ endogenous ligand, and APEL. APLN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of APLN antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4