Anti-adenylate kinase 3 antibodies are used in the immunodetection of the protein encoded by the AK3 gene. In humans, the canonical protein has a reported length of 227 amino acid residues and a mass of 25.6 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be highly expressed in heart, skeletal muscle and liver, moderately expressed in pancreas and kidney, and weakly expressed in placenta, brain and lung. A member of the Adenylate kinase protein family, it is known to be involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Other names for this target antigen include AK6, AKL3L1, FIX, GTP:AMP phosphotransferase AK3, mitochondrial, and AK3L1.