Anti-calmegin antibodies are used for the immunodetection of the protein encoded by the CLGN gene. In humans, the canonical protein has a reported length of 610 amino acid residues and a mass of 70 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in the testis. A member of the Calreticulin protein family, it is reported to function during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Other names for this target antigen include testis tissue sperm-binding protein Li 79P. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some calmegin antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.