Anti-HCN2 antibodies are used in the immunodetection of the protein hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. In humans, the canonical protein has a reported length of 889 amino acid residues and a mass of 97 kDa. Its subcellular localization is in the cell membrane. A member of the Potassium channel HCN protein family, HCN2 is known to be involved with cell to cell signaling and potassium ion transport. Post-translational modifications have been described, including phosphorylation and glycosylation. The HCN2 gene has been associated with the disease, Epilepsy. Synonyms for this target antigen include BCNG2, EIG17, GEFSP11, HAC-1, and BCNG-2. HCN2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.