Anti-CD180 molecule antibodies are used for the immunodetection of the protein encoded by the CD180 gene. In humans, the canonical protein has a reported length of 661 amino acid residues and a mass of 74.2 kDa. Its subcellular localization is in the cell membrane. It is noted to be expressed mainly on mature peripherical B cells. A member of the Toll-like receptor protein family, it is believed to cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include Ly78, RP105, CD180 antigen, lymphocyte antigen 64, lymphocyte antigen-64, radioprotective, 105kDa, and LY64. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.