Anti-abl-interactor 1 antibodies are used in the immunodetection of the protein encoded by the ABI1 gene. In humans, the canonical protein has a reported length of 508 amino acid residues and a mass of 55.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 12 different isoforms for this protein. It is found to be widely expressed, with highest expression in the brain. A member of the ABI protein family, it is believed to act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include E3B1, NAP1BP, SSH3BP, SSH3BP1, Abelson interactor 1, Abl-interactor protein 1 long, abl-binding protein 4, and ABLBP4.