Anti-POT1 antibodies are used in the immunodetection of the protein protection of telomeres 1. In humans, the canonical protein has a reported length of 634 amino acid residues and a mass of 71.4 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of a the Telombin protein family, POT1 is a known component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Synonyms for this target antigen include CRMCC3, GLM9, HPOT1, PFBMFT8, protection of telomeres protein 1, and CMM10.