Anti-OPTN antibodies are used in the immunodetection of the protein optineurin. In humans, the canonical protein has a reported length of 577 amino acid residues and a mass of 65.9 kDa. Its subcellular localization is in the cytoplasmic vesicles, Golgi, and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. OPTN is known to play an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, E3-14.7K-interacting protein, and ALS12. OPTN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 130 citations in the literature describe the use of OPTN antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.