Anti-AMBN antibodies are used in the immunodetection of the protein ameloblastin. In humans, the canonical protein has a reported length of 447 amino acid residues and a mass of 48.3 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 2 different isoforms have been reported for this protein. It is reported to have ameloblast-specific expression. A member of the Ameloblastin protein family, AMBN is reported to be involved in mineralization and structural organization of enamel. Post-translational modifications have been described, including glycosylation. The AMBN gene has been associated with the disease, Amelogenesis imperfecta 1F. Synonyms for this target antigen include AI1F and enamel matrix protein. AMBN gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Some AMBN antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.