Anti-WNT2 antibodies are used in the immunodetection of the protein Wnt family member 2. In humans, the canonical protein has a reported length of 360 amino acid residues and a mass of 40.4 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is reported to be expressed in the brain in the thalamus, in fetal and adult lung and in the placenta. A member of the Wnt protein family, WNT2 is known to be involved with the Wnt signaling pathway and cell to cell signaling. Post-translational modifications have been described, including glycosylation.
The WNT2 marker can be used to identify Type 1 Alveolar Fibroblast Cells.* Synonyms for this target antigen include IRP, protein Wnt-2, Int-1-related protein, epididymis secretory sperm binding protein, int-1-like protein 1, and INT1L1. WNT2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of WNT2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4