Anti-TIE1 antibodies are used in the immunodetection of the protein tyrosine kinase with immunoglobulin like and EGF like domains 1. In humans, the canonical protein has a reported length of 1138 amino acid residues and a mass of 125.1 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably expressed in developing vascular endothelial cells. A member of the Tyr protein kinase protein family, TIE1 is known to be involved with angiogenesis and in utero embryonic development.
The TIE1 marker can be used to identify Blood Vessel Endothelial Cells.* Synonyms for this target antigen include LMPHM11, TIE, tyrosine-protein kinase receptor Tie-1, tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1, and JTK14. TIE1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of TIE1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4