Anti-RYBP antibodies are used in the immunodetection of the protein RING1 and YY1 binding protein. In humans, the canonical protein has a reported length of 228 amino acid residues and a mass of 24.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably expressed in the tonsil, testis, placenta, oral mucosa, and esophagus. RYBP is a known component of the Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include APAP-1, DEDAF, YEAF1, DED-associated factor, YY1 and E4TF1 associated factor 1, and AAP1. RYBP gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of RYBP antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.