Anti-REN antibodies are used in the immunodetection of the protein renin. In humans, the canonical protein has a reported length of 406 amino acid residues and a mass of 45.1 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. A member of the Peptidase A1 protein family, REN is known to be involved with kidney development and male gonad development. Post-translational modifications have been described, including glycosylation.
The REN marker can be used to identify Juxtaglomerular Granular Cells.* Synonyms for this target antigen include HNFJ2, RTD, angiotensin-forming enzyme, angiotensinogenase, renin precursor, renal, and ADTKD4. REN gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 90 citations in the literature describe the use of REN antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4