Anti-GCLM antibodies are used in the immunodetection of the protein glutamate-cysteine ligase modifier subunit. In humans, the canonical protein has a reported length of 274 amino acid residues and a mass of 30.7 kDa. Up to 2 different isoforms have been reported for this protein. A member of the Aldo/keto reductase protein family, GCLM is known to be involved with pathways of aging and the apoptotic pathway. Synonyms for this target antigen include glutamate--cysteine ligase regulatory subunit, GCS light chain, GSC light chain, and GLCLR. GCLM gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 160 citations in the literature describe the use of GCLM antibodies in research. Western Blot is a widely used application for these antibodies. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.