Anti-NTN1 antibodies are used in the immunodetection of the protein netrin 1. In humans, the canonical protein has a reported length of 604 amino acid residues and a mass of 67.7 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is found to be widely expressed in normal adult tissues with highest levels in the heart, small intestine, colon, liver and prostate. NTN1 is known to be involved with the apoptotic pathway and cell adhesion. Post-translational modifications have been described, including glycosylation. The NTN1 marker can be used to identify Cerebellar Inhibitory Neurons.* Synonyms for this target antigen include MRMV4 and NET1. NTN1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 100 citations in the literature describe the use of NTN1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4