Anti-RGS18 antibodies are used in the immunodetection of the protein regulator of G protein signaling 18. In humans, the canonical protein has a reported length of 235 amino acid residues and a mass of 27.6 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver. RGS18 is known to inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
The RGS18 marker can be used to identify Non-Classical Or Patrolling Monocytes.* Synonyms for this target antigen include regulator of G-protein signalling 13 and regulator of G-protein signalling 18. RGS18 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of RGS18 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4