Anti-LGR6 antibodies are used in the immunodetection of the protein leucine rich repeat containing G protein-coupled receptor 6. In humans, the canonical protein has a reported length of 967 amino acid residues and a mass of 104.3 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the G-protein coupled receptor 1 protein family, LGR6 is a known receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Post-translational modifications have been described, including glycosylation.
The LGR6 marker can be used to identify Brain Astrocytes, Bronchial Smooth Muscle Cells, Tracheobronchial Smooth Muscle Cells, Bronchiolar Smooth Muscle Cells, and Perichondrial Fibroblasts.* Synonyms for this target antigen include gonadotropin receptor. LGR6 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4