Anti-DSG3 antibodies are used in the immunodetection of the protein desmoglein 3. In humans, the canonical protein has a reported length of 999 amino acid residues and a mass of 107.5 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the tonsil, skin, and esophagus. DSG3 is known to be a component of intercellular desmosome junctions. Post-translational modifications have been described, including glycosylation. The DSG3 gene has been associated with the disease, Blistering. Synonyms for this target antigen include CDHF6, PVA, 130 kDa pemphigus vulgaris antigen, cadherin family member 6, and ABOLM. DSG3 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 150 citations in the literature describe the use of DSG3 antibodies in research. Western Blot, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.