Anti-TPSAB1 antibodies are used in the immunodetection of the protein tryptase alpha/beta 1. In humans, the canonical protein has a reported length of 275 amino acid residues and a mass of 30.5 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the tonsil, rectum, lymph node, colon, and bone marrow. A member of the Peptidase S1 protein family, TPSAB1 is known to be involved with proteolysis. Post-translational modifications have been described, including glycosylation. The TPSAB1 marker can be used to identify Mast Cells, Tissue Resident Mucosal Type Mast Cells, and Connective Tissue Type Mast Cells.* Synonyms for this target antigen include TPS2, TPSB1, TPSB2, Tryptase-2, tryptase alpha/beta-1, and TPS1.
*HuBMAP Human Reference Atlas v1.4