Anti-SLC6A5 antibodies are used in the immunodetection of the protein solute carrier family 6 member 5. In humans, the canonical protein has a reported length of 797 amino acid residues and a mass of 87.4 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in medulla, and to a lesser extent in spinal cord and cerebellum. A member of the Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) protein family, SLC6A5 is known to be involved with chemical synaptic transmission.
The SLC6A5 marker can be used to identify Cerebellar Inhibitory Neurons, Pons Splatter Neurons, Medulla Oblongata Splatter Neurons, and Gray Matter Splatter Neurons.* Synonyms for this target antigen include GLYT2, HKPX3, NET1, sodium- and chloride-dependent glycine transporter 2, norepinephrine transporter 1, and GLYT-2. SLC6A5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chicken species. A number of SLC6A5 antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4