Anti-RIC8A antibodies are used in the immunodetection of the protein RIC8 guanine nucleotide exchange factor A. In humans, the canonical protein has a reported length of 531 amino acid residues and a mass of 59.7 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Synembryn protein family, RIC8A is known to be involved with GPCR signaling pathways and in utero embryonic development. Synonyms for this target antigen include synembryn-A and resistance to inhibitors of cholinesterase 8 homolog A. RIC8A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some RIC8A antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.