Anti-MTHFR antibodies are used in the immunodetection of the protein methylenetetrahydrofolate reductase. In humans, the canonical protein has a reported length of 656 amino acid residues and a mass of 74.6 kDa. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Methylenetetrahydrofolate reductase protein family, MTHFR is known to catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Synonyms for this target antigen include 5,10-methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolate reductase (NAD(P)H), and methylenetetrahydrofolate reductase (NADPH). MTHFR gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of MTHFR antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.