Anti-KCNK2 antibodies are used in the immunodetection of the protein potassium two pore domain channel subfamily K member 2. In humans, the canonical protein has a reported length of 426 amino acid residues and a mass of 47.1 kDa. Its subcellular localization is in the ER and cell membrane. Up to 4 different isoforms have been reported for this protein. A member of the Two pore domain potassium channel (TC 1.A.1.8) protein family, KCNK2 is reported to be an ion channel that contributes to passive transmembrane potassium transport. Post-translational modifications have been described, including phosphorylation and glycosylation.
The KCNK2 marker can be used to identify Medullary Fibroblasts.* Synonyms for this target antigen include TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e, potassium channel subfamily K member 2, and K2p2.1. KCNK2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of KCNK2 antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4