Anti-CTSH antibodies are used in the immunodetection of the protein cathepsin H. In humans, the canonical protein has a reported length of 335 amino acid residues and a mass of 37.4 kDa. Its subcellular localization is in the lysosomes. It is notably widely expressed in many tissue types. A member of the Peptidase C1 protein family, CTSH is known to be important for the overall degradation of proteins in lysosomes. Post-translational modifications have been described, including glycosylation.
The CTSH marker can be used to identify CD8?- Thymic Conventional Dendritic Cells.* Synonyms for this target antigen include ACC-5, ACC4, ACC5, CPSB, pro-cathepsin H, N-benzoylarginine-beta-naphthylamide hydrolase, aleurain, and ACC-4. CTSH gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. A number of CTSH antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4