Anti-OCRL antibodies are used in the immunodetection of the protein OCRL inositol polyphosphate-5-phosphatase. In humans, the canonical protein has a reported length of 901 amino acid residues and a mass of 104.2 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Inositol 1,4,5-trisphosphate 5-phosphatase type II protein family, OCRL is known to catalyze the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. The OCRL gene has been associated with the disease, Lowe oculocerebrorenal syndrome. Synonyms for this target antigen include Dent-2, INPP5F, LOCR, NPHL2, OCRL-1, OCRL1, inositol polyphosphate 5-phosphatase OCRL, and DENT2. OCRL gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.