Anti-LDB3 antibodies are used in the immunodetection of the protein LIM domain binding 3. In humans, the canonical protein has a reported length of 727 amino acid residues and a mass of 77.1 kDa. Its subcellular localization is in the cytoplasm. Up to 7 different isoforms have been reported for this protein. It is notably expressed in skeletal muscle and to a lesser extent in the heart. LDB3 is believed to function as a an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
The LDB3 marker can be used to identify Vascular Smooth Muscle Cells.* Synonyms for this target antigen include CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, and CMD1C. LDB3 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of LDB3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4