Anti-SCNN1G antibodies are used in the immunodetection of the protein sodium channel epithelial 1 subunit gamma. In humans, the canonical protein has a reported length of 649 amino acid residues and a mass of 74.3 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the kidney. A member of the Amiloride-sensitive sodium channel (TC 1.A.6) protein family, SCNN1G is known to be involved with the transport of ions. Post-translational modifications have been described, including glycosylation, ubiquitination, protein cleavage and phosphorylation.
The SCNN1G marker can be used to identify Type 2 Distal Convoluted Tubule Cells, Connecting Tubule Cells, Connecting Tubule Principal Cells, Collecting Duct Principal Cells, and Cortical Collecting Duct Principal Cells.* Synonyms for this target antigen include ENaCg, ENaCgamma, LDLS2, PHA1, PHA1B3, SCNEG, amiloride-sensitive sodium channel subunit gamma, and BESC3. SCNN1G gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4