Anti-MLANA antibodies are used in the immunodetection of the protein melan-A. In humans, the canonical protein has a reported length of 118 amino acid residues and a mass of 13.2 kDa. Its subcellular localization is in the ER and Golgi. It is notably expressed in the testis, skin, and retina. MLANA is known to be involved in melanosome biogenesis by ensuring the stability of GPR143. The MLANA marker can be used to identify Melanocytes.* Synonyms for this target antigen include MART1, melanoma antigen recognized by T-cells 1, antigen LB39-AA, antigen SK29-AA, epididymis secretory sperm binding protein, and MART-1. MLANA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 200 citations in the literature describe the use of MLANA antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Flow Cytometry, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4