Anti-ATP8B1 antibodies are used in the immunodetection of the protein ATPase phospholipid transporting 8B1. In humans, the canonical protein has a reported length of 1251 amino acid residues and a mass of 143.7 kDa. Its subcellular localization is in the ER, Golgi, and cell membrane. It is notably widely expressed in many tissue types. A member of the Cation transport ATPase (P-type) (TC 3.A.3) protein family, ATP8B1 is reported to be a catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. The ATP8B1 gene has been associated with the disease, Cholestasis. Synonyms for this target antigen include BRIC, FIC1, ICP1, PFIC, PFIC1, and ATPIC. ATP8B1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. ELISA is a widely used application for the ATP8B1 antibodies listed below. In addition, Immunohistochemistry is also a common application.