Anti-ARRB2 antibodies are used in the immunodetection of the protein arrestin beta 2. In humans, the canonical protein has a reported length of 409 amino acid residues and a mass of 46.1 kDa. Its subcellular localization is in the cell membrane, nucleus, cytoplasmic vesicles, and cytoplasm. Up to 5 different isoforms have been reported for this protein. A member of the Arrestin protein family, ARRB2 is reported to function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. Synonyms for this target antigen include ARR2, BARR2, beta-arrestin-2, non-visual arrestin-3, and ARB2. ARRB2 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Over 150 citations in the literature describe the use of ARRB2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.