Anti-RIC8B antibodies are used in the immunodetection of the protein RIC8 guanine nucleotide exchange factor B. In humans, the canonical protein has a reported length of 520 amino acid residues and a mass of 58.8 kDa. Its subcellular localization is in the cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Synembryn protein family, RIC8B is known to be involved with GPCR signaling pathways. Synonyms for this target antigen include hSyn, synembryn-B, brain synembrin, brain synembryn, resistance to inhibitors of cholinesterase 8 homolog B, and RIC8. RIC8B gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some RIC8B antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.