Anti-P2RY1 antibodies are used in the immunodetection of the protein purinergic receptor P2Y1. In humans, the canonical protein has a reported length of 373 amino acid residues and a mass of 42.1 kDa. Its subcellular localization is in the cell membrane. It is notably widely expressed in many tissue types. A member of the G-protein coupled receptor 1 protein family, P2RY1 is a known receptor for extracellular adenine nucleotides such as ADP. Post-translational modifications have been described, including glycosylation.
The P2RY1 marker can be used to identify Dorsal Excitatory Neurons.* Synonyms for this target antigen include SARCC, P2Y purinoceptor 1, ADP receptor, ATP receptor, P2 purinoceptor subtype Y1, and P2Y1. P2RY1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 80 citations in the literature describe the use of P2RY1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4