Anti-JAM2 antibodies are used in the immunodetection of the protein junctional adhesion molecule 2. In humans, the canonical protein has a reported length of 298 amino acid residues and a mass of 33.2 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in the heart, placenta, lung, foreskin and lymph node. A member of the Immunoglobulin protein superfamily, JAM2 is known to be involved with cell adhesion and spermatid development. Post-translational modifications have been described, including glycosylation.
The JAM2 marker can be used to identify Blood Vessel Endothelial Cells.* Synonyms for this target antigen include JAM-IT/VE-JAM, vascular endothelial junction-associated molecule, and junctional adhesion molecule B. JAM2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of JAM2 antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4