Anti-GZMM antibodies are used in the immunodetection of the protein granzyme M. In humans, the canonical protein has a reported length of 257 amino acid residues and a mass of 27.5 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is notably expressed in the tonsil, spleen, lymph node, lung, and bone marrow. A member of the Peptidase S1 protein family, GZMM is known to be involved with the apoptotic pathway and innate immune responses. Post-translational modifications have been described, including glycosylation.
The GZMM marker can be used to identify Mature CD8 Single-Positive Thymocytes and Immature NKT Cells.* Synonyms for this target antigen include MET1, HU-Met-1, Met-1 serine protease, lymphocyte met-ase 1, met-ase, and LMET1. GZMM gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of GZMM antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4