Anti-TRPC3 antibodies are used in the immunodetection of the protein transient receptor potential cation channel subfamily C member 3. In humans, the canonical protein has a reported length of 921 amino acid residues and a mass of 105.5 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. A member of the Transient receptor (TC 1.A.4) protein family, TRPC3 is known to be involved with the transport of ions.
The TRPC3 marker can be used to identify Upper-Layer Intratelencephalic Neurons.* Synonyms for this target antigen include TRP3, short transient receptor potential channel 3, hTrp-3, transient receptor protein 3, and SCA41. TRPC3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of TRPC3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4