Anti-SLC6A3 antibodies are used in the immunodetection of the protein solute carrier family 6 member 3. In humans, the canonical protein has a reported length of 620 amino acid residues and a mass of 68.5 kDa. Its subcellular localization is in the cell membrane. It is reported to be highly expressed in substantia nigra. A member of the Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) protein family, SLC6A3 is known to mediate sodium- and chloride-dependent transport of dopamine. Post-translational modifications have been described, including glycosylation.
The SLC6A3 marker can be used to identify Midbrain Splatter Neurons.* Synonyms for this target antigen include DAT1, PKDYS, PKDYS1, sodium-dependent dopamine transporter, DA transporter, and DAT. SLC6A3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 180 citations in the literature describe the use of SLC6A3 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4