Anti-ADAM17 antibodies are used in the immunodetection of the protein ADAM metallopeptidase domain 17. In humans, the canonical protein has a reported length of 824 amino acid residues and a mass of 93 kDa. Its subcellular localization is in the membrane. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. ADAM17 is known to be involved with B cell differentiation and cell adhesion. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation. The ADAM17 gene has been associated with the disease, Inflammatory skin and bowel disease. Synonyms for this target antigen include CD156B, CSVP, NISBD, NISBD1, TACE, and ADAM18. ADAM17 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.