Anti-RNASE1 antibodies are used in the immunodetection of the protein ribonuclease A family member 1, pancreatic. In humans, the canonical protein has a reported length of 156 amino acid residues and a mass of 17.6 kDa. It has been described to be a secreted protein. It is notably expressed in many tissues, such as the appendix and cerebellum. A member of the Pancreatic ribonuclease protein family, RNASE1 is a reported endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Post-translational modifications have been described, including glycosylation.
The RNASE1 marker can be used to identify Brain Oligodendrocytes, Thymic Macrophages, Blood Vessel Endothelial Cells, Thymic Cortical Macrophages, and Thymic Medullary Macrophages.* Synonyms for this target antigen include RIB1, RNS1, ribonuclease pancreatic, HP-RNase, RIB-1, RNase A, RNase upI-1, and RAC1. RNASE1 gene orthologs have been reported in the mouse, rat and chimpanzee species. A number of RNASE1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4