Anti-BMX antibodies are used in the immunodetection of the protein BMX non-receptor tyrosine kinase. In humans, the canonical protein has a reported length of 675 amino acid residues and a mass of 78 kDa. Its subcellular localization is in the cytoplasm. It is reported to be highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. A member of the Tyr protein kinase protein family, BMX is a type of non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis.
The BMX marker can be used to identify Artery Endothelial Cells and Type 4 Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include PSCTK2, PSCTK3, cytoplasmic tyrosine-protein kinase BMX, BTK-like on X chromosome, Etk/Bmx cytosolic tyrosine kinase, and ETK. BMX gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of BMX antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4