Anti-Agrin antibodies are used for the immunodetection of the protein encoded by the AGRN gene. In humans, the canonical protein has a reported length of 2068 amino acid residues and a mass of 217.3 kDa. Its subcellular localization is in the extracellular matrix. Alternative splicing is reported to yield 7 different isoforms for this protein. It is reported to be expressed in basement membranes of lung and kidney. It is noted to be involved in the regulation of transcription and signal transduction pathways. Post-translational modifications have been described, including protein cleavage and glycosylation. The gene encoding this protein is implicated in Myasthenic syndrome. Other names for this target antigen include agrin proteoglycan. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.