Anti-AIM2 antibodies are used in the immunodetection of the protein absent in melanoma 2. In humans, the canonical protein has a reported length of 343 amino acid residues and a mass of 39 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be expressed in spleen, small intestine, peripheral blood leukocytes, and testis. A member of a the HIN-200 protein family, AIM2 is reported to be a sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis. Synonyms for this target antigen include PYHIN4 and interferon-inducible protein AIM2.